Katharina Kummer

Metabolic and cardiovascular effects of progesterone receptor modulation by Ulipristal in Cyp17a1(d/d)xApoe(d/d) mice

Katharina Kummer is a medical student in the clinical phase of her studies at the University of Lübeck and is currently pursuing her doctoral thesis at the Institute of Experimental and Clinical Pharmacology and Toxicology within the research group of Prof. Dr. Walter Raasch. 

Her project focuses on the metabolic and cardiovascular effects of progesterone receptor modulation by Ulipristal in Cyp17a1 knockout mice with additional ApoE knockout. 
The enzyme Cyp17a1 plays a central role in the biosynthesis of sex hormones such as estrogen and testosterone. Cyp17a1 knockout mice exhibit a deficiency in those hormones. This hormonal imbalance results in pronounced atherosclerosis in male mice and severe obesity in female mice. One of the aims of the project is to investigate whether modulation of the progesterone receptor can prevent weight gain in female mice. 

Katharina Kummer is a guest member of the iRTG.