Prof. Dr. rer. nat. Martin Kircher

Photo of Martin  Kircher

Institut für Humangenetik

Universität zu Lübeck
Ratzeburger Allee 160
23562 Lübeck

Email: martin.kircher(at)


D. Reich, R. Green, M. Kircher, J. Krause, N. Patterson, E. Durand, B. Viola, A. Briggs, U. Stenzel, P. Johnson, T. Maricic, J. Good, T. Marques-Bonet, C. Alkan, Q. Fu, S. Mallick, H. Li, M. Meyer, E. Eichler, M. Stoneking, M. Richards, S. Talamo, M. Shunkov, A. Derevianko, J. Hublin, J. Kelso, M. Slatkin, and S. Pääbo,
Genetic history of an archaic hominin group from Denisova Cave in Siberia, Nature , vol. 468, no. 7327, pp. 1053-1060.
P. Kleinert, and M. Kircher,
A framework to score the effects of structural variants in health and disease, Genome Res , vol. 32, no. 4, pp. 766-777, 2022.
P. Rentzsch, M. Schubach, J. Shendure, and M. Kircher,
CADD-Splice-improving genome-wide variant effect prediction using deep learning-derived splice scores, Genome Med , vol. 13, no. 1, pp. 31, 2021.
M. Kircher, C. Xiong, B. Martin, M. Schubach, F. Inoue, R. Bell, J. Costello, J. Shendure, and N. Ahituv,
Saturation mutagenesis of twenty disease-associated regulatory elements at single base-pair resolution, Nat Commun , vol. 10, no. 1, pp. 3583, 2019.
F. Inoue, M. Kircher, B. Martin, G. Cooper, D. Witten, M. McManus, N. Ahituv, and J. Shendure,
A systematic comparison reveals substantial differences in chromosomal versus episomal encoding of enhancer activity, Genome Res , vol. 27, no. 1, pp. 38-52, 2017.
M. Snyder, M. Kircher, A. Hill, R. Daza, and J. Shendure,
Cell-free DNA Comprises an In Vivo Nucleosome Footprint that Informs Its Tissues-Of-Origin, Cell , vol. 164, no. 1-2, pp. 57-68, 2016.
M. Kircher, D. Witten, P. Jain, B. O'Roak, G. Cooper, and J. Shendure,
A general framework for estimating the relative pathogenicity of human genetic variants, Nat Genet , vol. 46, no. 3, pp. 310-5, 2014.
M. Meyer, M. Kircher, M. Gansauge, H. Li, F. Racimo, S. Mallick, J. Schraiber, F. Jay, K. Prufer, C. Filippo, P. Sudmant, C. Alkan, Q. Fu, R. Do, N. Rohland, A. Tandon, M. Siebauer, R. Green, K. Bryc, A. Briggs, U. Stenzel, J. Dabney, J. Shendure, J. Kitzman, M. Hammer, M. Shunkov, A. Derevianko, N. Patterson, A. Andres, E. Eichler, M. Slatkin, D. Reich, J. Kelso, and S. Paabo,
A high-coverage genome sequence from an archaic Denisovan individual, Science , vol. 338, no. 6104, pp. 222-6, 2012.
M. Kircher, S. Sawyer, and M. Meyer,
Double indexing overcomes inaccuracies in multiplex sequencing on the Illumina platform, Nucleic Acids Res , vol. 40, no. 1, pp. e3, 2012.
M. Kircher, U. Stenzel, and J. Kelso,
Improved base calling for the Illumina Genome Analyzer using machine learning strategies, Genome Biol , vol. 10, no. 8, pp. R83, 2009.